Tag: narrow therapeutic index
Digoxin and Amiodarone: How to Prevent Life-Threatening Drug Interactions
Digoxin and amiodarone together can cause deadly toxicity. Learn why a 50% digoxin dose reduction is mandatory when starting amiodarone, how to monitor for danger signs, and what alternatives exist.
Immunosuppressants: Cyclosporine and Tacrolimus Generic Issues
Generic versions of cyclosporine and tacrolimus save money but carry serious risks for transplant patients due to narrow therapeutic windows. Small changes in absorption can trigger rejection or toxicity-monitoring and consistency are critical.